Laparoscopic sleeve gastrectomy is now the most common procedure in overweight surgery worldwide. About 80% of the stomach is resected with the effect of a smaller capacity of the stomach and a faster satiety. Furthermore, sleeve gastrectomy is characterized by hormonal mechanisms of action. The procedure is performed laparoscopically and is characterized by a very good quality of life. In order to achieve a satisfactory weight reduction in the long term, a lifelong follow up is mandatory.